Drug interactions
Amiodarone + Umeclidinium-vilanterol
Severity: Major
Amiodarone and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this risk through tachycardia and a fall in potassium.
What this interaction means in plain words
Amiodarone and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and adrenergic cardiac stimulation.
What to do
Monitor ECG, QTc, potassium and magnesium, and correct any abnormality. Consider an alternative bronchodilator if QTc lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Amiodarone and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this risk through tachycardia and a fall in potassium.
How serious is the interaction between Amiodarone and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, QTc, potassium and magnesium, and correct any abnormality. Consider an alternative bronchodilator if QTc lengthens significantly.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amitriptyline, Amoxapine. The full list is on the Umeclidinium-vilanterol page.
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