Drug interactions
Acetylsalicylic acid + Argatroban
Severity: Major
Acetylsalicylic acid and Argatroban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is a direct thrombin inhibitor and aspirin impairs platelet function, so together they raise the risk of bleeding. The combination is sometimes used in PCI or heparin-induced thrombocytopenia.
What this interaction means in plain words
Acetylsalicylic acid and Argatroban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Argatroban belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment via thrombin inhibition and platelet inhibition.
What to do
Monitor aPTT or ACT per protocol and watch for bleeding. Use the lowest effective aspirin dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Acetylsalicylic acid with Argatroban?
MediHelp rates the interaction as major. Acetylsalicylic acid and Argatroban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Argatroban is a direct thrombin inhibitor and aspirin impairs platelet function, so together they raise the risk of bleeding. The combination is sometimes used in PCI or heparin-induced thrombocytopenia.
How serious is the interaction between Acetylsalicylic acid and Argatroban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or ACT per protocol and watch for bleeding. Use the lowest effective aspirin dose.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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