Drug interactions
Argatroban + Defibrotide
Severity: Contraindicated
Argatroban and Defibrotide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.
What this interaction means in plain words
Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Argatroban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
Why it happens
Additive antithrombotic and profibrinolytic effects increase bleeding tendency.
What to do
Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Argatroban
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
- Alteplase + Argatroban Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Defibrotide + Enoxaparin Contraindicated
Frequently asked questions
Can I take Argatroban with Defibrotide?
MediHelp rates the interaction as contraindicated. Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.
How serious is the interaction between Argatroban and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Argatroban page.
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