Drug reference
argatroban
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Miscellaneous(CVS))
Mechanism of action
Competitive, direct thrombin inhibitor that reversibly binds to thrombin active site; thrombin enables fibrinogen conversion to fibrin during the coagulation cascade
Common side effects
- Dyspnea
- Hematuria
- Fever
- Hypotension
- Chest Pain
- Hemoglobin and hematocrit decrease
- GI bleeding
Known interactions (11)
- argatroban + mifepristone Contraindicated
- abciximab + argatroban Major
- argatroban + eptifibatide Major
- argatroban + tirofiban Major
- anagrelide + argatroban Moderate
- argatroban + bazedoxifene-conjugated estrogens Moderate
- argatroban + cilostazol Moderate
- argatroban + clopidogrel Moderate
- argatroban + dipyridamole Moderate
- argatroban + estradiol Moderate
- argatroban + ticlopidine Moderate
Related conditions
Frequently asked questions
What drug class is argatroban?
argatroban belongs to: Cardiovascular.
How does argatroban work?
Competitive, direct thrombin inhibitor that reversibly binds to thrombin active site; thrombin enables fibrinogen conversion to fibrin during the coagulation cascade
What are the common side effects of argatroban?
Dyspnea, Hematuria, Fever, Hypotension, Chest Pain, Hemoglobin and hematocrit decrease, GI bleeding
Which drugs interact with argatroban?
mifepristone, abciximab, eptifibatide, tirofiban, anagrelide, bazedoxifene-conjugated estrogens, cilostazol, clopidogrel, dipyridamole, estradiol, ticlopidine
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