Drug interactions
Arginine + Isosorbide dinitrate
Severity: Moderate
Arginine and Isosorbide dinitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arginine is a nitric oxide precursor and can lower blood pressure. With a nitrate, the vasodilating effects may be additive, leading to hypotension or dizziness.
What this interaction means in plain words
Arginine and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nitric oxide-mediated vasodilation.
What to do
Monitor blood pressure and advise patients about orthostatic symptoms. Avoid arginine supplementation unless supervised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Arginine with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Arginine and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arginine is a nitric oxide precursor and can lower blood pressure. With a nitrate, the vasodilating effects may be additive, leading to hypotension or dizziness.
How serious is the interaction between Arginine and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise patients about orthostatic symptoms. Avoid arginine supplementation unless supervised.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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