Drug reference
isosorbide dinitrate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Organic Nitrates)
Mechanism of action
Vasodilating agent (nitric oxide donor); relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial oxygen demand; also improves coronary collateral circulation, lowering blood pressure, increasing heart rate, and causing occasional paradoxical bradycardia
Common side effects
- Restlessness
- Dizziness
- Headache
- Nausea
- Methemoglobinemia
Contraindications
- Hypersensitivity Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life Severe anemia, shock, markedly low blood…
Known interactions (4)
- avanafil + isosorbide dinitrate Contraindicated
- isosorbide dinitrate + sildenafil Contraindicated
- isosorbide dinitrate + tadalafil Contraindicated
- isosorbide dinitrate + vardenafil Contraindicated
Related conditions
Frequently asked questions
What drug class is isosorbide dinitrate?
isosorbide dinitrate belongs to: Cardiovascular.
How does isosorbide dinitrate work?
Vasodilating agent (nitric oxide donor); relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial oxygen demand; also improves coronary collateral circulation, lowering blood pressure, increasing heart rate, and causing occasional paradoxical bradycardia
What are the common side effects of isosorbide dinitrate?
Restlessness, Dizziness, Headache, Nausea, Methemoglobinemia
Which drugs interact with isosorbide dinitrate?
avanafil, sildenafil, tadalafil, vardenafil
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.