Drug interactions
Arginine + Isosorbide mononitrate
Severity: Moderate
Arginine and Isosorbide mononitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arginine boosts nitric oxide production and may add to the vasodilating effect of isosorbide mononitrate. This can lead to hypotension and dizziness.
What this interaction means in plain words
Arginine and Isosorbide mononitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through increased nitric oxide substrate and nitrate-derived nitric oxide.
What to do
Monitor blood pressure and symptoms of hypotension when arginine is used with isosorbide mononitrate. Reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Frequently asked questions
Can I take Arginine with Isosorbide mononitrate?
MediHelp rates the interaction as moderate. Arginine and Isosorbide mononitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arginine boosts nitric oxide production and may add to the vasodilating effect of isosorbide mononitrate. This can lead to hypotension and dizziness.
How serious is the interaction between Arginine and Isosorbide mononitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when arginine is used with isosorbide mononitrate. Reduce the dose if needed.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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