Drug reference
isosorbide mononitrate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Organic Nitrates)
Mechanism of action
Organic nitrate that causes systemic venodilation, decreasing preload; enters vascular smooth muscle and is converted to nitric oxide, leading to activation of cyclic guanosine monophosphate and vasodilation, Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial O2
Common side effects
- Dizziness
- Headache
- Nausea
- Hypotension
- Methemoglobinemia
Contraindications
- Hypersensitivity to organic nitrates PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil); concomitant use can cause severe hypotension, syncope, or myocardial ischemia Concomitant administration with guanylate stimulator riociguat (may cause hypotension)
Known interactions (5)
- avanafil + isosorbide mononitrate Contraindicated
- isosorbide mononitrate + sildenafil Contraindicated
- isosorbide mononitrate + tadalafil Contraindicated
- isosorbide mononitrate + vardenafil Contraindicated
- isosorbide mononitrate + metoprolol Moderate
Related conditions
Frequently asked questions
What drug class is isosorbide mononitrate?
isosorbide mononitrate belongs to: Cardiovascular.
How does isosorbide mononitrate work?
Organic nitrate that causes systemic venodilation, decreasing preload; enters vascular smooth muscle and is converted to nitric oxide, leading to activation of cyclic guanosine monophosphate and vasodilation, Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial O2
What are the common side effects of isosorbide mononitrate?
Dizziness, Headache, Nausea, Hypotension, Methemoglobinemia
Which drugs interact with isosorbide mononitrate?
avanafil, sildenafil, tadalafil, vardenafil, metoprolol
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