Drug interactions
Aripiprazole + Calcium / magnesium / potassium / sodium oxybates
Severity: Major
Aripiprazole and Calcium / magnesium / potassium / sodium oxybates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause profound CNS and respiratory depression. Adding an antipsychotic can increase sedation and the risk of respiratory depression, coma or death.
What this interaction means in plain words
Aripiprazole and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression.
What to do
Avoid the combination if possible. If necessary, use the lowest doses and monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Carbamazepine Major
- Aripiprazole + Cisapride Major
Frequently asked questions
Can I take Aripiprazole with Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates the interaction as major. Aripiprazole and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates cause profound CNS and respiratory depression. Adding an antipsychotic can increase sedation and the risk of respiratory depression, coma or death.
How serious is the interaction between Aripiprazole and Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, use the lowest doses and monitor closely for sedation and respiratory depression.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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