Drug interactions
Artemether + Ofloxacin
Severity: Moderate
Artemether and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether (usually given with lumefantrine) can prolong the QT interval, and ofloxacin may add to this effect. The combination raises the possibility of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Artemether and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation via cardiac potassium channel blockade.
What to do
Use another antibiotic if possible. If both are needed, check ECG and electrolytes and monitor QTc during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Artemether with Ofloxacin?
MediHelp rates the interaction as moderate. Artemether and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether (usually given with lumefantrine) can prolong the QT interval, and ofloxacin may add to this effect. The combination raises the possibility of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Artemether and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use another antibiotic if possible. If both are needed, check ECG and electrolytes and monitor QTc during treatment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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