Drug interactions
Artemether + Pazopanib
Severity: Major
Artemether and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both pazopanib and artemether (usually given with lumefantrine) can prolong the QT interval. Giving them together may raise the chance of torsades de pointes, particularly with electrolyte disturbances or heart disease. Artemether is also a weak CYP3A4 substrate, so exposure changes are possible.
What this interaction means in plain words
Artemether and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination where an alternative antimalarial is available. If it is unavoidable, check a baseline ECG, correct potassium and magnesium, and monitor the ECG during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Artemether with Pazopanib?
MediHelp rates the interaction as major. Artemether and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both pazopanib and artemether (usually given with lumefantrine) can prolong the QT interval. Giving them together may raise the chance of torsades de pointes, particularly with electrolyte disturbances or heart disease. Artemether is also a weak CYP3A4 substrate, so exposure changes are possible.
How serious is the interaction between Artemether and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antimalarial is available. If it is unavoidable, check a baseline ECG, correct potassium and magnesium, and monitor the ECG during treatment.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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