Drug interactions
Amiodarone + Pazopanib
Severity: Major
Amiodarone and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes. Amiodarone's CYP3A4 and P-glycoprotein inhibition may also raise pazopanib exposure, adding hepatotoxicity risk.
What this interaction means in plain words
Amiodarone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation plus amiodarone inhibition of CYP3A4 and P-glycoprotein.
What to do
Avoid if possible; otherwise obtain baseline and serial ECGs, correct potassium and magnesium, and monitor liver function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
- Arsenic trioxide + Pazopanib Major
Frequently asked questions
Can I take Amiodarone with Pazopanib?
MediHelp rates the interaction as major. Amiodarone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes. Amiodarone's CYP3A4 and P-glycoprotein inhibition may also raise pazopanib exposure, adding hepatotoxicity risk.
How serious is the interaction between Amiodarone and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain baseline and serial ECGs, correct potassium and magnesium, and monitor liver function.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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