Drug interactions
Artemether / lumefantrine + Atorvastatin
Severity: Minor
Artemether / lumefantrine and Atorvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine may reduce atorvastatin concentrations, potentially weakening lipid lowering. Short antimalarial courses make clinical impact limited.
What this interaction means in plain words
Artemether / lumefantrine and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether may induce CYP3A4, increasing atorvastatin metabolism.
What to do
No dose change is usually needed for a short course; recheck lipids if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Artemether / lumefantrine with Atorvastatin?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether/lumefantrine may reduce atorvastatin concentrations, potentially weakening lipid lowering. Short antimalarial courses make clinical impact limited.
How serious is the interaction between Artemether / lumefantrine and Atorvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for a short course; recheck lipids if therapy is prolonged.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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