Drug interactions
Artemether / lumefantrine + Deflazacort
Severity: Moderate
Artemether / lumefantrine and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a CYP3A4 inducer and may lower exposure to the active metabolite of deflazacort. This may reduce efficacy.
What this interaction means in plain words
Artemether / lumefantrine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases clearance of deflazacort's active metabolite.
What to do
Monitor clinical response to deflazacort during and after the antimalarial course. Consider a dose increase if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Deflazacort?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether is a CYP3A4 inducer and may lower exposure to the active metabolite of deflazacort. This may reduce efficacy.
How serious is the interaction between Artemether / lumefantrine and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to deflazacort during and after the antimalarial course. Consider a dose increase if response is lost.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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