Drug interactions
Artemether / lumefantrine + Docetaxel
Severity: Minor
Artemether / lumefantrine and Docetaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can weakly induce CYP3A4, which might slightly lower docetaxel exposure. The effect is probably small and is of uncertain clinical relevance, particularly with the short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether may increase docetaxel metabolism.
What to do
No routine adjustment is needed. Be aware of possible reduced docetaxel effect and monitor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Frequently asked questions
Can I take Artemether / lumefantrine with Docetaxel?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can weakly induce CYP3A4, which might slightly lower docetaxel exposure. The effect is probably small and is of uncertain clinical relevance, particularly with the short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Docetaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be aware of possible reduced docetaxel effect and monitor response.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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