Drug interactions
Atazanavir + Docetaxel
Severity: Major
Atazanavir and Docetaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can substantially increase docetaxel exposure. This raises the risk of severe neutropenia, infection, mucositis, neuropathy and fluid retention. Boosted regimens with ritonavir or cobicistat make the effect larger.
What this interaction means in plain words
Atazanavir and Docetaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Docetaxel belongs to Oncology.
Why it happens
Atazanavir inhibits CYP3A4, reducing hepatic and intestinal metabolism of docetaxel.
What to do
Prefer a non-CYP3A4-inhibiting antiretroviral such as an integrase inhibitor-based regimen. If unavoidable, reduce the docetaxel dose and monitor blood counts and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Docetaxel
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Docetaxel?
MediHelp rates the interaction as major. Atazanavir and Docetaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can substantially increase docetaxel exposure. This raises the risk of severe neutropenia, infection, mucositis, neuropathy and fluid retention. Boosted regimens with ritonavir or cobicistat make the effect larger.
How serious is the interaction between Atazanavir and Docetaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting antiretroviral such as an integrase inhibitor-based regimen. If unavoidable, reduce the docetaxel dose and monitor blood counts and toxicity closely.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Belatacept, Ceritinib. The full list is on the Docetaxel page.
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