Drug interactions
Artemether / lumefantrine + Eribulin
Severity: Major
Artemether / lumefantrine and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and eribulin has a similar effect. The combination raises the risk of QT-related arrhythmias, particularly in patients with electrolyte disturbances.
What this interaction means in plain words
Artemether / lumefantrine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid concurrent use when an alternative antimalarial or oncology regimen is possible. If it cannot be avoided, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Artemether / lumefantrine and Eribulin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eribulin
- Adagrasib + Eribulin Major
- Amiodarone + Eribulin Major
- Amisulpride + Eribulin Major
- Anagrelide + Eribulin Major
- Arsenic trioxide + Eribulin Major
- Asenapine + Eribulin Major
Frequently asked questions
Can I take Artemether / lumefantrine with Eribulin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine can prolong the QT interval, and eribulin has a similar effect. The combination raises the risk of QT-related arrhythmias, particularly in patients with electrolyte disturbances.
How serious is the interaction between Artemether / lumefantrine and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when an alternative antimalarial or oncology regimen is possible. If it cannot be avoided, correct electrolytes and monitor the ECG.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
