Drug interactions
Asenapine + Eribulin
Severity: Major
Asenapine and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and asenapine adds a similar effect. The combination may increase arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Asenapine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Obtain ECG and correct potassium and magnesium before starting and monitor ECG during concurrent use. Consider an alternative antipsychotic if QTc increases markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Eribulin
Frequently asked questions
Can I take Asenapine with Eribulin?
MediHelp rates the interaction as major. Asenapine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval and asenapine adds a similar effect. The combination may increase arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Asenapine and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and correct potassium and magnesium before starting and monitor ECG during concurrent use. Consider an alternative antipsychotic if QTc increases markedly.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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