Drug interactions
Artemether / lumefantrine + Erlotinib
Severity: Minor
Artemether / lumefantrine and Erlotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and may modestly lower erlotinib exposure. The clinical consequence is probably small given the short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether increases erlotinib metabolism.
What to do
No routine dose change is needed for a short course. Monitor tumour response if the combination is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Artemether / lumefantrine with Erlotinib?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and may modestly lower erlotinib exposure. The clinical consequence is probably small given the short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Erlotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a short course. Monitor tumour response if the combination is prolonged.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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