Drug interactions
Amobarbital + Erlotinib
Severity: Major
Amobarbital and Erlotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce CYP3A4 and lower erlotinib plasma concentrations. Reduced exposure may compromise antitumor efficacy.
What this interaction means in plain words
Amobarbital and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Erlotinib belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 accelerates erlotinib metabolism.
What to do
Avoid the combination where possible and choose a non-inducing anticonvulsant or sedative. If it must be used, monitor tumor response and consider an erlotinib dose increase per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Erlotinib
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
- Enzalutamide + Erlotinib Major
Frequently asked questions
Can I take Amobarbital with Erlotinib?
MediHelp rates the interaction as major. Amobarbital and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital can induce CYP3A4 and lower erlotinib plasma concentrations. Reduced exposure may compromise antitumor efficacy.
How serious is the interaction between Amobarbital and Erlotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-inducing anticonvulsant or sedative. If it must be used, monitor tumor response and consider an erlotinib dose increase per labeling.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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