Drug interactions
Artemether / lumefantrine + Fesoterodine
Severity: Minor
Artemether / lumefantrine and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and artemether may induce CYP3A4, so the exposure to fesoterodine's active metabolite could shift in either direction. The net clinical effect is uncertain and likely small.
What this interaction means in plain words
Artemether / lumefantrine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on CYP2D6 (inhibition) and CYP3A4 (induction) pathways of 5-hydroxymethyltolterodine formation and clearance.
What to do
Monitor for anticholinergic adverse effects or loss of bladder symptom control during the short antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Artemether / lumefantrine with Fesoterodine?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine inhibits CYP2D6 and artemether may induce CYP3A4, so the exposure to fesoterodine's active metabolite could shift in either direction. The net clinical effect is uncertain and likely small.
How serious is the interaction between Artemether / lumefantrine and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects or loss of bladder symptom control during the short antimalarial course.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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