Drug interactions
Artemether / lumefantrine + Fingolimod
Severity: Major
Artemether / lumefantrine and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both artemether and lumefantrine can prolong the QT interval, and fingolimod causes bradycardia and may add to QT risk. The combination may raise the chance of torsades de pointes.
What this interaction means in plain words
Artemether / lumefantrine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with fingolimod-related bradycardia.
What to do
Prefer an antimalarial with less QT effect during fingolimod therapy. If used, obtain a baseline ECG, correct potassium and magnesium and monitor heart rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Fingolimod?
MediHelp rates the interaction as major. Artemether / lumefantrine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both artemether and lumefantrine can prolong the QT interval, and fingolimod causes bradycardia and may add to QT risk. The combination may raise the chance of torsades de pointes.
How serious is the interaction between Artemether / lumefantrine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antimalarial with less QT effect during fingolimod therapy. If used, obtain a baseline ECG, correct potassium and magnesium and monitor heart rhythm.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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