Drug interactions
Artemether / lumefantrine + Galantamine
Severity: Moderate
Artemether / lumefantrine and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP2D6 inhibitor and may raise galantamine exposure. This could increase cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope.
What this interaction means in plain words
Artemether / lumefantrine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated galantamine metabolism by lumefantrine.
What to do
Monitor for nausea, vomiting and bradycardia during the antimalarial course. Reduce the galantamine dose if cholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Artemether / lumefantrine with Galantamine?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a CYP2D6 inhibitor and may raise galantamine exposure. This could increase cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope.
How serious is the interaction between Artemether / lumefantrine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, vomiting and bradycardia during the antimalarial course. Reduce the galantamine dose if cholinergic effects appear.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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