Drug interactions
Artemether / lumefantrine + Lorlatinib
Severity: Moderate
Artemether / lumefantrine and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both components of artemether/lumefantrine are CYP3A4 substrates, and lorlatinib may induce this enzyme. Lower antimalarial exposure risks treatment failure.
What this interaction means in plain words
Artemether / lumefantrine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by lorlatinib increases metabolism of artemether and lumefantrine.
What to do
Monitor for treatment failure and parasitological response, and consider an alternative antimalarial if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Lorlatinib?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both components of artemether/lumefantrine are CYP3A4 substrates, and lorlatinib may induce this enzyme. Lower antimalarial exposure risks treatment failure.
How serious is the interaction between Artemether / lumefantrine and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and parasitological response, and consider an alternative antimalarial if feasible.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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