Drug reference
lorlatinib
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Neoplastics)
Mechanism of action
ALK/ROS1 tyrosine kinase inhibitor, ALK and ROS1 kinases promote tumor progression in ALK/ROS1 positive lung cancer; lorlatinib binds to and inhibits both kinases, which leads to a disruption of the ALK- and ROS1-mediated signaling; this disruption can subsequently inhibit tumor cell growth in ALK- and ROS1-overexpressing tumor cells
Common side effects
- Anemia
- Edema
- Hyperglycemia
- Peripheral neuropathy
- Hypertriglyceridemia
- Hypercholesterolemia
- Increased ALT & AST
Known interactions (6)
- amobarbital + lorlatinib Contraindicated
- apalutamide + lorlatinib Contraindicated
- carbamazepine + lorlatinib Contraindicated
- enzalutamide + lorlatinib Contraindicated
- efavirenz + lorlatinib Major
- bosentan + lorlatinib Moderate
Related conditions
Frequently asked questions
What drug class is lorlatinib?
lorlatinib belongs to: Oncology.
How does lorlatinib work?
ALK/ROS1 tyrosine kinase inhibitor, ALK and ROS1 kinases promote tumor progression in ALK/ROS1 positive lung cancer; lorlatinib binds to and inhibits both kinases, which leads to a disruption of the ALK- and ROS1-mediated signaling; this disruption can subsequently inhibit tumor cell growth in ALK- and ROS1-overexpressing tumor cells
What are the common side effects of lorlatinib?
Anemia, Edema, Hyperglycemia, Peripheral neuropathy, Hypertriglyceridemia, Hypercholesterolemia, Increased ALT & AST
Which drugs interact with lorlatinib?
amobarbital, apalutamide, carbamazepine, enzalutamide, efavirenz, bosentan
Full monographs, dosing and an interaction checker in the MediHelp app
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