Drug interactions
Artemether / lumefantrine + Metformin-repaglinide
Severity: Minor
Artemether / lumefantrine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and lumefantrine is metabolized by CYP3A4, so repaglinide exposure could fall somewhat. The clinical impact is expected to be small and short-lived given the 3-day treatment course.
What this interaction means in plain words
Artemether / lumefantrine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether may increase repaglinide metabolism.
What to do
No dose change is generally needed; check blood glucose during the malaria treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Artemether / lumefantrine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and lumefantrine is metabolized by CYP3A4, so repaglinide exposure could fall somewhat. The clinical impact is expected to be small and short-lived given the 3-day treatment course.
How serious is the interaction between Artemether / lumefantrine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; check blood glucose during the malaria treatment course.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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