Drug interactions
Artemether / lumefantrine + Pazopanib
Severity: Moderate
Artemether / lumefantrine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, adding to the QT effect of pazopanib. Artemether is also a weak CYP3A4 inducer, which could lower pazopanib exposure, although the effect over a short antimalarial course is probably limited.
What this interaction means in plain words
Artemether / lumefantrine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, plus possible modest CYP3A4 induction reducing pazopanib levels.
What to do
Check a baseline ECG and electrolytes and monitor QTc during the antimalarial course. Consider deferring pazopanib if the malaria treatment can safely be separated, and monitor for reduced pazopanib effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Artemether / lumefantrine with Pazopanib?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can prolong the QT interval, adding to the QT effect of pazopanib. Artemether is also a weak CYP3A4 inducer, which could lower pazopanib exposure, although the effect over a short antimalarial course is probably limited.
How serious is the interaction between Artemether / lumefantrine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor QTc during the antimalarial course. Consider deferring pazopanib if the malaria treatment can safely be separated, and monitor for reduced pazopanib effect.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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