Drug interactions
Artemether / lumefantrine + Prednisolone
Severity: Minor
Artemether / lumefantrine and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has been reported to induce CYP3A4 modestly with repeated dosing, which could lower prednisolone exposure. Because antimalarial courses are short, any reduction in steroid effect is probably small.
What this interaction means in plain words
Artemether / lumefantrine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by artemether, increasing prednisolone clearance.
What to do
No routine adjustment is needed. Watch for reduced steroid response in patients with serious conditions and increase the steroid dose if there is clinical loss of effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Prednisolone?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has been reported to induce CYP3A4 modestly with repeated dosing, which could lower prednisolone exposure. Because antimalarial courses are short, any reduction in steroid effect is probably small.
How serious is the interaction between Artemether / lumefantrine and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for reduced steroid response in patients with serious conditions and increase the steroid dose if there is clinical loss of effect.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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