Drug interactions
Artemether / lumefantrine + Tadalafil
Severity: Minor
Artemether / lumefantrine and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 inducing activity, which may modestly lower tadalafil exposure. Reduced erectile or pulmonary hypertension efficacy is possible but the effect is probably small.
What this interaction means in plain words
Artemether / lumefantrine and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak induction of CYP3A4 by artemether increases tadalafil metabolism.
What to do
No routine dose change; assess response to tadalafil during and after the short antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Tadalafil?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 inducing activity, which may modestly lower tadalafil exposure. Reduced erectile or pulmonary hypertension efficacy is possible but the effect is probably small.
How serious is the interaction between Artemether / lumefantrine and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; assess response to tadalafil during and after the short antimalarial course.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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