Drug interactions
Artemether / lumefantrine + Tamoxifen
Severity: Minor
Artemether / lumefantrine and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can induce CYP3A4 with repeated dosing, but a short antimalarial course makes a meaningful effect on tamoxifen unlikely.
What this interaction means in plain words
Artemether / lumefantrine and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak, transient CYP3A4 induction by artemether.
What to do
No dose adjustment is needed for a standard short course. Be aware of potential reduced tamoxifen effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Artemether / lumefantrine with Tamoxifen?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can induce CYP3A4 with repeated dosing, but a short antimalarial course makes a meaningful effect on tamoxifen unlikely.
How serious is the interaction between Artemether / lumefantrine and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for a standard short course. Be aware of potential reduced tamoxifen effect.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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