Drug interactions
Artemether / lumefantrine + Vinorelbine
Severity: Minor
Artemether / lumefantrine and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 induction effects, which could modestly lower vinorelbine exposure. Clinical significance is uncertain and no meaningful loss of efficacy has been well documented.
What this interaction means in plain words
Artemether / lumefantrine and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by artemether lowering vinorelbine metabolism-dependent exposure.
What to do
No dose adjustment is generally needed. Monitor for reduced response to vinorelbine if given together over an extended period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Artemether / lumefantrine with Vinorelbine?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 induction effects, which could modestly lower vinorelbine exposure. Clinical significance is uncertain and no meaningful loss of efficacy has been well documented.
How serious is the interaction between Artemether / lumefantrine and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for reduced response to vinorelbine if given together over an extended period.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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