Drug interactions
Cyclosporin + Vinorelbine
Severity: Major
Cyclosporin and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin inhibits CYP3A4 and P-glycoprotein and may increase vinorelbine exposure. This could worsen neutropenia, neuropathy and constipation.
What this interaction means in plain words
Cyclosporin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Vinorelbine belongs to Oncology.
Why it happens
Cyclosporin inhibits CYP3A4 metabolism and P-glycoprotein efflux of vinorelbine.
What to do
Monitor blood counts frequently, and watch for neurotoxicity and constipation. Reduce the vinorelbine dose if toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Cyclosporin with Vinorelbine?
MediHelp rates the interaction as major. Cyclosporin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporin inhibits CYP3A4 and P-glycoprotein and may increase vinorelbine exposure. This could worsen neutropenia, neuropathy and constipation.
How serious is the interaction between Cyclosporin and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently, and watch for neurotoxicity and constipation. Reduce the vinorelbine dose if toxicity occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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