Drug interactions
Asenapine + Atenolol-chlorthalidone
Severity: Moderate
Asenapine and Atenolol-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 blocking activity that can cause orthostatic hypotension. With atenolol and chlorthalidone the hypotensive effect is increased, raising the risk of dizziness and falls.
What this interaction means in plain words
Asenapine and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Atenolol-chlorthalidone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from asenapine alpha-1 antagonism and antihypertensive therapy.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing asenapine, and reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Atenolol-chlorthalidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Atenolol-chlorthalidone?
MediHelp rates the interaction as moderate. Asenapine and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-1 blocking activity that can cause orthostatic hypotension. With atenolol and chlorthalidone the hypotensive effect is increased, raising the risk of dizziness and falls.
How serious is the interaction between Asenapine and Atenolol-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing asenapine, and reduce antihypertensive doses if hypotension develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
