Drug interactions
Asenapine + Atenolol
Severity: Moderate
Asenapine and Atenolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 blockade, and atenolol lowers blood pressure and blunts reflex tachycardia. Combined use may increase dizziness and syncope risk, especially at initiation.
What this interaction means in plain words
Asenapine and Atenolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Atenolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic antagonism and beta blockade.
What to do
Monitor blood pressure including orthostatic readings when starting asenapine or changing doses, and counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Atenolol?
MediHelp rates the interaction as moderate. Asenapine and Atenolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 blockade, and atenolol lowers blood pressure and blunts reflex tachycardia. Combined use may increase dizziness and syncope risk, especially at initiation.
How serious is the interaction between Asenapine and Atenolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings when starting asenapine or changing doses, and counsel patients to rise slowly.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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