Drug interactions
Asenapine + Atomoxetine
Severity: Moderate
Asenapine and Atomoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval, so combining them may raise the risk of arrhythmia, especially in patients with risk factors. Atomoxetine can also increase heart rate and blood pressure.
What this interaction means in plain words
Asenapine and Atomoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Atomoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor QTc, heart rate and blood pressure. Choose an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Atomoxetine?
MediHelp rates the interaction as moderate. Asenapine and Atomoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval, so combining them may raise the risk of arrhythmia, especially in patients with risk factors. Atomoxetine can also increase heart rate and blood pressure.
How serious is the interaction between Asenapine and Atomoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor QTc, heart rate and blood pressure. Choose an alternative if QTc becomes prolonged.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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