Drug interactions
Asenapine + Buprenorphine subdermal implant
Severity: Moderate
Asenapine and Buprenorphine subdermal implant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval and adds to sedation and respiratory depression when used with an antipsychotic. Steady implant exposure means the effect persists and is not quickly reversible.
What this interaction means in plain words
Asenapine and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive effects on cardiac repolarization.
What to do
Monitor for sedation and respiratory depression, particularly after starting asenapine or raising its dose. Obtain an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Buprenorphine subdermal implant?
MediHelp rates the interaction as moderate. Asenapine and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval and adds to sedation and respiratory depression when used with an antipsychotic. Steady implant exposure means the effect persists and is not quickly reversible.
How serious is the interaction between Asenapine and Buprenorphine subdermal implant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly after starting asenapine or raising its dose. Obtain an ECG if other QT risk factors exist.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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