Drug interactions
Asenapine + Butalbital
Severity: Moderate
Asenapine and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that causes sedation, and asenapine adds to this effect. Together they may cause marked drowsiness and psychomotor impairment.
What this interaction means in plain words
Asenapine and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and antipsychotic receptor blockade.
What to do
Limit butalbital use and monitor for oversedation. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Butalbital?
MediHelp rates the interaction as moderate. Asenapine and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that causes sedation, and asenapine adds to this effect. Together they may cause marked drowsiness and psychomotor impairment.
How serious is the interaction between Asenapine and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit butalbital use and monitor for oversedation. Advise against driving and alcohol.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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