Drug interactions
Asenapine + Carvedilol
Severity: Moderate
Asenapine and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension, and carvedilol adds to this effect. Asenapine also weakly inhibits CYP2D6, which might modestly raise carvedilol levels.
What this interaction means in plain words
Asenapine and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Carvedilol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects plus weak CYP2D6 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Reduce the dose of either drug if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Carvedilol?
MediHelp rates the interaction as moderate. Asenapine and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension, and carvedilol adds to this effect. Asenapine also weakly inhibits CYP2D6, which might modestly raise carvedilol levels.
How serious is the interaction between Asenapine and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Reduce the dose of either drug if symptomatic.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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