Drug interactions
Asenapine + Deferasirox
Severity: Moderate
Asenapine and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2 and may raise exposure to CYP1A2 substrates such as asenapine. Higher asenapine levels could increase sedation, hypotension and QT effects.
What this interaction means in plain words
Asenapine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Deferasirox belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated asenapine metabolism by deferasirox.
What to do
Monitor for increased sedation, orthostatic hypotension and QT effects. Consider reducing the asenapine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Asenapine with Deferasirox?
MediHelp rates the interaction as moderate. Asenapine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2 and may raise exposure to CYP1A2 substrates such as asenapine. Higher asenapine levels could increase sedation, hypotension and QT effects.
How serious is the interaction between Asenapine and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, orthostatic hypotension and QT effects. Consider reducing the asenapine dose if adverse effects occur.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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