Drug interactions
Asenapine + Dextroamphetamine
Severity: Minor
Asenapine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a weak CYP2D6 inhibitor, and amphetamines are partly metabolised by CYP2D6, so a small rise in exposure is theoretically possible. A clinically meaningful effect is unlikely, and amphetamine also has substantial renal elimination.
What this interaction means in plain words
Asenapine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated dextroamphetamine metabolism by asenapine.
What to do
No dose change is routinely needed; monitor for increased stimulant effects such as tachycardia, agitation or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Dextroamphetamine?
MediHelp rates the interaction as minor. Asenapine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is a weak CYP2D6 inhibitor, and amphetamines are partly metabolised by CYP2D6, so a small rise in exposure is theoretically possible. A clinically meaningful effect is unlikely, and amphetamine also has substantial renal elimination.
How serious is the interaction between Asenapine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for increased stimulant effects such as tachycardia, agitation or insomnia.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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