Drug interactions
Asenapine + Doxazosin
Severity: Moderate
Asenapine and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 antagonist activity and can cause orthostatic hypotension. Combined with doxazosin the hypotensive effect may be increased, with a risk of dizziness, syncope and falls.
What this interaction means in plain words
Asenapine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Doxazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade.
What to do
Monitor orthostatic blood pressure, especially during initiation and dose increases, and reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Doxazosin?
MediHelp rates the interaction as moderate. Asenapine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-1 antagonist activity and can cause orthostatic hypotension. Combined with doxazosin the hypotensive effect may be increased, with a risk of dizziness, syncope and falls.
How serious is the interaction between Asenapine and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure, especially during initiation and dose increases, and reduce the antihypertensive dose if symptomatic.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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