Drug interactions
Asenapine + Ergoloid mesylates
Severity: Minor
Asenapine and Ergoloid mesylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates have dopaminergic and serotonergic activity that may oppose or modify antipsychotic effects. Theoretical concern exists for serotonin toxicity or neuroleptic malignant syndrome, but clinical evidence is scant.
What this interaction means in plain words
Asenapine and Ergoloid mesylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible overlapping serotonergic and dopaminergic receptor effects; the mechanism is theoretical and not well established.
What to do
No routine change is needed, but monitor for fever, rigidity, agitation or autonomic instability when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Ergoloid mesylates?
MediHelp rates the interaction as minor. Asenapine and Ergoloid mesylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergoloid mesylates have dopaminergic and serotonergic activity that may oppose or modify antipsychotic effects. Theoretical concern exists for serotonin toxicity or neuroleptic malignant syndrome, but clinical evidence is scant.
How serious is the interaction between Asenapine and Ergoloid mesylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed, but monitor for fever, rigidity, agitation or autonomic instability when starting or adjusting either drug.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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