Drug interactions
Asenapine + Esketamine
Severity: Moderate
Asenapine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and may cause orthostatic hypotension, while esketamine causes sedation and dissociation. Combined use may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Asenapine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and blood pressure during and after esketamine dosing, and advise against driving on treatment days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Esketamine?
MediHelp rates the interaction as moderate. Asenapine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and may cause orthostatic hypotension, while esketamine causes sedation and dissociation. Combined use may increase drowsiness and psychomotor impairment.
How serious is the interaction between Asenapine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine dosing, and advise against driving on treatment days.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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