Drug interactions
Asenapine + Ethinylestradiol
Severity: Minor
Asenapine and Ethinylestradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is metabolized partly by CYP1A2, and ethinylestradiol is a weak CYP1A2 inhibitor. Asenapine levels may rise modestly, with a small increase in sedation or other dose-related effects.
What this interaction means in plain words
Asenapine and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ethinylestradiol weakly inhibits CYP1A2, reducing the clearance of asenapine.
What to do
No routine adjustment is needed. Watch for increased sedation or orthostatic hypotension when starting an estrogen-containing contraceptive in a patient stabilized on asenapine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Ethinylestradiol?
MediHelp rates the interaction as minor. Asenapine and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is metabolized partly by CYP1A2, and ethinylestradiol is a weak CYP1A2 inhibitor. Asenapine levels may rise modestly, with a small increase in sedation or other dose-related effects.
How serious is the interaction between Asenapine and Ethinylestradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased sedation or orthostatic hypotension when starting an estrogen-containing contraceptive in a patient stabilized on asenapine.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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