Drug interactions
Asenapine + Ethotoin
Severity: Moderate
Asenapine and Ethotoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is a hydantoin anticonvulsant that can cause drowsiness and dizziness, and asenapine adds to sedation. Antipsychotics may also lower the seizure threshold, which could affect seizure control.
What this interaction means in plain words
Asenapine and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; asenapine may also lower seizure threshold, opposing anticonvulsant effect.
What to do
Monitor for sedation and for any change in seizure frequency after starting asenapine. Adjust anticonvulsant therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Ethotoin?
MediHelp rates the interaction as moderate. Asenapine and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin is a hydantoin anticonvulsant that can cause drowsiness and dizziness, and asenapine adds to sedation. Antipsychotics may also lower the seizure threshold, which could affect seizure control.
How serious is the interaction between Asenapine and Ethotoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any change in seizure frequency after starting asenapine. Adjust anticonvulsant therapy as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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