Drug interactions
Asenapine + Givinostat
Severity: Major
Asenapine and Givinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QTc interval, and asenapine has a similar effect. Combined use may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Asenapine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Avoid the combination where possible. If unavoidable, obtain ECGs at initiation and during concurrent use, correct electrolytes, and withhold the drugs if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Givinostat
Frequently asked questions
Can I take Asenapine with Givinostat?
MediHelp rates the interaction as major. Asenapine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QTc interval, and asenapine has a similar effect. Combined use may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Asenapine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, obtain ECGs at initiation and during concurrent use, correct electrolytes, and withhold the drugs if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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