Drug interactions
Asenapine + Glibenclamide
Severity: Moderate
Asenapine and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can raise blood glucose and may weaken the glycemic control provided by glyburide. Patients with diabetes may need treatment adjustment after starting the antipsychotic.
What this interaction means in plain words
Asenapine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Glibenclamide belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose sulfonylurea glucose lowering; the exact mechanism is not fully established.
What to do
Monitor glucose and HbA1c more frequently after starting or changing asenapine. Adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Asenapine with Glibenclamide?
MediHelp rates the interaction as moderate. Asenapine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can raise blood glucose and may weaken the glycemic control provided by glyburide. Patients with diabetes may need treatment adjustment after starting the antipsychotic.
How serious is the interaction between Asenapine and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c more frequently after starting or changing asenapine. Adjust the glyburide dose as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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