Drug interactions
Asenapine + Indacaterol inhaled
Severity: Moderate
Asenapine and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can prolong the QT interval and cause hypokalemia, and asenapine also prolongs QT. Together they may increase the risk of ventricular arrhythmia, especially in patients with cardiac disease.
What this interaction means in plain words
Asenapine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-2 agonist-related hypokalemia and tachycardia adding to the risk.
What to do
Monitor ECG and serum potassium in patients with heart disease or other QT-prolonging drugs. Use recommended indacaterol doses only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Asenapine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can prolong the QT interval and cause hypokalemia, and asenapine also prolongs QT. Together they may increase the risk of ventricular arrhythmia, especially in patients with cardiac disease.
How serious is the interaction between Asenapine and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with heart disease or other QT-prolonging drugs. Use recommended indacaterol doses only.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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