Drug interactions
Asenapine + Insulin lispro
Severity: Moderate
Asenapine and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can impair glucose tolerance and cause hyperglycemia, potentially reducing the effect of insulin lispro. Dose requirements may change after the antipsychotic is introduced.
What this interaction means in plain words
Asenapine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Insulin lispro belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose insulin action; the exact mechanism is not fully established.
What to do
Monitor blood glucose more frequently after starting or changing asenapine. Adjust insulin lispro doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Insulin lispro
Frequently asked questions
Can I take Asenapine with Insulin lispro?
MediHelp rates the interaction as moderate. Asenapine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can impair glucose tolerance and cause hyperglycemia, potentially reducing the effect of insulin lispro. Dose requirements may change after the antipsychotic is introduced.
How serious is the interaction between Asenapine and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing asenapine. Adjust insulin lispro doses as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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