Drug interactions
Asenapine + Insulin nph
Severity: Moderate
Asenapine and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine may cause hyperglycemia and insulin resistance, reducing the effect of NPH insulin and worsening glycemic control. Insulin dose requirements may increase.
What this interaction means in plain words
Asenapine and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition: antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Check blood glucose more often when asenapine is started or changed, and adjust NPH insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Insulin nph?
MediHelp rates the interaction as moderate. Asenapine and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine may cause hyperglycemia and insulin resistance, reducing the effect of NPH insulin and worsening glycemic control. Insulin dose requirements may increase.
How serious is the interaction between Asenapine and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when asenapine is started or changed, and adjust NPH insulin dose as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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